PCOS & Oxidative Stress
Did you know that women with PCOS have higher oxidative stress than women without PCOS? Higher oxidative stress causes hormonal imbalances and metabolism issues that might have a negative impact on their health. So this article is going to tell you everything you need to know about PCOS and oxidative stress. From what it is to how to manage and deal with it.
What is the definition of oxidative stress?
An imbalance between the synthesis and accumulation of oxygen reactive species (ROS) in cells and tissues, as well as the ability of a biological system to detoxify these reactive products, causes oxidative stress.
So basically put, our body’s develop ROS (free radicals) which is usually neutralized by body’s defense mechanisms, i.e, antioxidants. When there is an imbalance, that is, more ROS is produced than the body’s ability to neutralise them, then there is disturbance which leads to oxidative stress.
ROS were thought to have only harmful effects and were linked to a variety of diseases. Oxidative stress occurs when ROS overwhelms the cellular antioxidant defense mechanism, resulting in oxidative damage to nucleic acids, proteins, and lipids. ROS has been linked to carcinogenesis (the transformation of healthy cells into cancer cells), neurotoxicity (the loss of function of neurons), atherosclerosis (plaque buildup inside arteries), diabetes, and ageing.
In polycystic ovarian syndrome (PCOS), oxidative stress has a big role.
Many studies have demonstrated that patients with PCOS have much higher levels of oxidative stress than the general population. Obesity, insulin resistance, hyperandrogenemia, and chronic inflammation are all found to be highly linked with oxidative stress levels.
The following are the roles of oxidative stress in PCOS:
• Polycystic Ovary Syndrome (PCOS) with Oxidative Stress:
Excess ROS accumulating in vivo would cause cell, protein, and lipid damage, and oxidative stress (OS) represents an imbalance between generation and scavenging of reactive oxygen/nitrogen species (ROS/RNS).
● Oxidative Stress, Obesity, and Polycystic Ovary Syndrome (PCOS) -
Obesity is a common endocrine disorder that affects people all around the world. Obese people are predicted to have higher levels of oxidative stress (OS) and substantial relationships between OS indicators and obesity indices like BMI and WC.
● Oxidative Stress, Insulin Resistance, and Polycystic Ovary Syndrome (PCOS)-
Insulin resistance (IR) is a physiological condition in which a particular dose of insulin has a different biological effect than predicted because cells fail to respond to the hormone insulin's typical actions, resulting in glucose transport and utilisation dysfunctions. PCOS women have a higher rate of insulin resistance, which leads to oxidative stress.
● Oxidative Stress, Chronic Inflammation, and Polycystic Ovary Syndrome (PCOS) -
Low-grade chronic inflammation is thought to be a key component of (PCOS) and oxidative stress.
● Oxidative Stress, Hyperandrogenemia, and Polycystic Ovary Syndrome (PCOS) -
Hyperandrogenemia (high levels of androgens in females) is a common symptom of PCOS, with 70 percent to 80 percent of women with hyperandrogenemia also having PCOS. In PCOS, oxidative stress (OS) and inflammation appear to play a role in hyperandrogenemia.
Polycystic Ovary Syndrome and Cancers:
Polycystic ovarian syndrome appears to be linked to an increased risk of reproductive tract cancers, particularly endometrial cancer (PCOS).
● Contributions of Oxidative Stress to Cancer Pathogenesis -
In culture and in vivo, oxidative stress (OS), which is changed in PCOS, increases in malignant cells compared to normal cells. OS can cause genetic variation directly through DNA damage, such as DNA chain rupture, base modification, DNA-DNA crosslinking, DNA-protein crosslinking, and epigenetic changes, such as increased DNA methylation levels, all of which play essential roles in cancer development.
● Oxidative Stress-Induced DNA Damage in Polycystic Ovary Syndrome (PCOS)-
DNA strand breakage and H2O2-induced DNA damage are significantly higher in women with PCOS.
● Obesity and Endometrial Cancer -
Obesity can aggravate OS and is often related with PCOS. It is also linked to endometrial hyperplasia and endometrial cancer, making it one of the most important risk factors for endometrial cancer.
● Insulin Resistance and Endometrial Cancer -
Insulin resistance (IR), which is related with OS independent of weight, is another common hallmark of PCOS and endometrial cancer, and is thought to be a possible mechanism of endometrial hyperplasia and endometrial cancer pathogenesis in PCOS.
● Estrogen and Endometrial Cancer -
Endometrial hyperplasia and cancer are thought to be caused by extended exposure to unopposed oestrogen in the lack of adequate progesterone, which is triggered by denominator anovulation.
● Polycystic Ovary Syndrome (PCOS) and Other Cancers -
Women with PCOS had a 2.5-fold increased risk of ovarian cancer (95 percent confidence interval [CI]), with the link being higher among women who have never taken oral contraception.
Antioxidants that are best for PCOS
An antioxidant present in the skin of grapes, berries, red wine, and peanuts has showed promise in helping women with polycystic ovarian syndrome regain hormone balance and fertility (PCOS).
PCOS and antioxidants
PCOS is a condition characterized by a considerable reduction in antioxidants and a higher risk of oxidative damage. Antioxidant supplementation has been demonstrated to improve insulin sensitivity in PCOS patients, which could improve the result of PCOS treatment.
PCOS and Stress
PCOS is known to induce stress, especially when it comes to the condition's physical signs, such as excessive facial and body hair. Anxiety and sadness might result from this stress. Younger PCOS women are more likely to be affected.
PCOS has an emotional component
Many women with PCOS suffer from depression and other mood problems. Others suffer from low-level mood disorders such as impatience, drowsiness, and a quick temper. The fact that PCOS can make a woman feel physically uneasy, emotionally insecure, or unfeminine just adds to the problem.
Is PCOS linked to mental illness?
PCOS is linked to a higher incidence of depression, anxiety, bipolar illness, and obsessive-compulsive disorder diagnoses. It's linked to worsening sadness, anxiety, OCD, and somatization symptoms. Screening for these illnesses in order to intervene early may be necessary. This demonstrates that PCOS can result in mental disorders.
Anxiety medication for PCOS
Antidepressants and anti-anxiety medications have not been studied especially for treating persons with PCOS, although they may be taken in the same manner they are for those without PCOS. Medications that help the body use insulin may help patients with PCOS feel less depressed.
Anxiety attacks and PCOS
People with PCOS are three times more likely than those without the condition to be diagnosed with anxiety and depression. PCOS patients are also more likely to experience anxiety and depression symptoms, which are more likely to be severe.
Although PCOS can’t be cured it can be managed so that it doesn’t become worse over time. With proper exercise and diet, this can be done. But a diet doesn’t give you the necessary nutrients for managing PCOS so always use supplements as well.
Chicnutrix Cysterhood and Cysterhood Inositol are such supplements that help in managing PCOS. Cysterhood is manufactured using Swiss Effervescent Technology and prepared with clinically tested components, 600 mg of N-acetylcysteine, and Vitamin C, resulting in a well-balanced mix that supports hormone and ovarian health from the inside out. Balances the hormones via way of means of decreasing androgens and testosterone. It additionally regulates the menstrual cycle, reduces inflammation and oxidative stress, helps ovulation, improves reproductive health and insulin resistance. It is doctor approved & vegetarian, gluten-free – Gentle on the Stomach & Great on taste in a splendid strawberry flavour.
Cysterhood Inositol is made up of a proprietary blend of scientifically proven ratios of Myo-inositol to D-chiro-inositol (Caronositol®): Vegan Vitamin D3, Vitamin B9 (Folate), and Chromium in a 3.6:1 ratio. It aids in the reduction of high insulin levels, which decreases insulin resistance, as well as the regulation of ovulatory cycles, which aids in the improvement of fertility, the reduction of inflammation, and the balancing of hormones. It aids in the prevention of Vitamin D3 deficiency and the management of PCOS weight. The MI: DCI ratio of 3.6:1 has been shown to boost the pregnancy rate by 65.5 percent. It's manufactured with clinically proven components, is vegan and gluten-free, and is doctor-approved. In natural raspberry flavour, it is gentle on the stomach and delicious to have.
This Ultimate Duo will help you reduce oxidative stress and become #StrongerThanPCOS!!